Individuals with higher levels of autoantibodies were also more likely to suffer from higher blood pressure. The use of ARBs in such individuals correlated with better control of their blood pressure, suggesting a possible personalized medicine approach to high blood pressure treatment in older adults. Elevated levels of these autoantibodies have long been linked to autoimmune disorders, such as malignant hypertension, transplant rejection and pre-eclampsia, a pregnancy complication marked by high blood pressure. The cause of elevated autoantibodies, however, has been elusive. Some older adults become frail as they age, and this frailty has been associated with chronic inflammation. To examine the relationship between autoantibody levels and frailty, the research team first recruited 255 participants ages 20 to 93 in Baltimore, Maryland. Participants were separated into two categories: 169 younger adults (ages 20 to 69) and 87 older adults (70 and older). The team measured blood levels of autoantibodies and found that older adults had nearly twice the levels of autoantibodies than the younger adults — a median of 7.3 micrograms per milliliter of blood compared to the younger adult group’s median level of 3.76. The researchers then used a frailty screening tool to identify frail older adults by measuring grip strength and walking speed, and asking questions about weight loss, fatigue and levels of physical activity. Older adults with high autoantibody levels were 3.9 times more likely to be frail.
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Portuguese giants Porto, European champions in 1987 and 2004, host Leicester City in their final group stage match wary of FC Copenhagen pipping them to second in Group G. site webDespite a woeful defence of their Premier League crown, Leicester are guaranteed to finish top of their section in Europe and avoid the likes of Barcelona and Atletico Madrid in the next round. And the Foxes could well decide which team joins them in the knockout phase with Copenhagen, third in the group, trailing Porto by two points ahead of a trip to pointless Club Brugge. Porto halted a run of five straight draws courtesy of teenager Rui Pedro’s 95th-minute winner over Braga at the weekend, ending a club record run of 520 minutes without a goal. “What matters is that we won three points and we are going to try to take advantage of this to continue to grow and believe,” said Porto coach Nuno Espirito Santo. “I believe the results haven’t been showing what we do.” Porto will secure their passage to the last 16 with victory over Leicester, but anything less will open the door for Copenhagen, who have a head-to-head advantage over the Portuguese on away goals. http://url.ondeweb.in/medicalinterview99086“We kept a clean sheet, and now we just have to go Brugge and get a victory – and then hope that Leicester do their job and beat Porto,” said Copenhagen’s Swedish international Erik Johansson after last month’s 0-0 home draw against Porto. Copenhagen, unbeaten domestically this term, stretched their lead in Denmark to 11 points on Saturday after securing an eighth successive win with a 1-0 defeat of Randers. – Lyon plot Sevilla scalp – Three-time reigning Europa League champions Sevilla are favourites to advance alongside Juventus in Group H, with Lyon needing to beat the Spaniards by at least two goals at Parc OL.
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